{"title":"BEST","description":"","products":[{"product_id":"nmn","title":"\u003ctc\u003eNMN Pterostillbene 60 Capsules\u003c\/tc\u003e","description":"\u003ctc\u003e\u003cdiv id=\"tab-1\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"plus-tab-customizing\"\u003e\u003cdiv class=\"plus-tab-customizing-title\"\u003e\u003ch3\u003eWhat is the NMN Pterostilbene?\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-container\"\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-1')\"\u003e What Makes ROKIT NMN Special \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-1\" class=\"accordion-content\"\u003e\u003cp\u003eNMN (Nicotinamide Mononucleotide) is a precursor to NAD+, a vital coenzyme found in all cells of the body. NAD+ plays an essential role in various biological processes, including energy metabolism, DNA repair, and the regulation of cellular aging.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/1._NAD.gif?v=1732689254\" alt=\"NMN 이미지\" class=\"responsive-image\" \u003e\u003cp\u003eNAD+ levels naturally decline with age, but this can be supplemented through NMN intake. Since NAD+ itself cannot be absorbed directly into the body, consuming NMN, which converts to NAD+ within the body, is the most effective method. Harvard University’s pioneering aging researcher, David A. Sinclair, highlighted NMN supplementation as a key to managing aging in his book Lifespan: Why We Age – and Why We Don’t Have To bringing global attention to its potential benefits.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/2._NMN.jpg?v=1732689555\" alt=\"NMN 분자구조\" class=\"responsive-image\" \u003e\u003cp\u003eROKIT America, in collaboration with ROKIT Healthcare, is spearheading the global anti-aging market by utilizing rigorously verified \"ROKIT NMN\" ingredients. The exceptional qualities of ROKIT NMN products are as follows:\u003c\/p\u003e\u003ch3\u003eScience-Based Research:\u003c\/h3\u003e\u003cp\u003eROKIT America develops its products based on the safety testing results of ROKIT NMN conducted jointly with ROKIT Healthcare. To validate the safety of NMN, it is essential to confirm the absence of toxicity in the raw materials through comprehensive toxicity testing. This is a critical factor in building trust in the product. ROKIT Healthcare has conducted the following tests to demonstrate the safety of ROKIT NMN:\u003c\/p\u003e\u003cdiv class=\"button-container\"\u003e\u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/rokit_nmn_toxicity_test_safety_experiment_1\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Single-Dose Toxicity Test Results\u003c\/a\u003e \u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/%EB%A1%9C%ED%82%B7%EC%95%84%EB%A9%94%EB%A6%AC%EC%B9%B4-%EC%97%B0%EA%B5%AC%EC%9E%90%EB%A3%8C-nmn-%EB%8F%85%EC%84%B1%EC%8B%9C%ED%97%98-%EC%95%88%EC%A0%84%EC%84%B1-%ED%8F%89%EA%B0%80-%EB%B0%98%EB%B3%B5%ED%88%AC%EC%97%AC\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Repeated-Dose Toxicity Test Results\u003c\/a\u003e \u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/%EB%A1%9C%ED%82%B7%EC%95%84%EB%A9%94%EB%A6%AC%EC%B9%B4-%EC%97%B0%EA%B5%AC%EC%9E%90%EB%A3%8C-nmn%EC%9D%98-%EC%9C%A0%EC%A0%84-%EB%8F%85%EC%84%B1%EC%8B%9C%ED%97%98-%EB%B3%B5%EA%B7%80%EB%8F%8C%EC%97%B0%EB%B3%80%EC%9D%B4-%ED%8F%89%EA%B0%80\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Reproductive and Developmental Toxicity Test Results\u003c\/a\u003e\u003c\/div\u003e\u003ch3\u003eHigh Purity and Superior Absorption:\u003c\/h3\u003e\u003cp\u003eROKIT America’s NMN products are manufactured with 99.9% purity, ensuring exceptional absorption within the body. The product is formulated with precise amounts of high-quality raw materials to maximize its effectiveness at the cellular level.\u003c\/p\u003e\u003ch3\u003eSafety and Verified Quality:\u003c\/h3\u003e\u003cp\u003eEach ROKIT NMN product undergoes stringent quality control measures and is manufactured in compliance with international standards. This ensures the delivery of safe and reliable products that users can trust.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-2')\"\u003e What is Pterostilbene? \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-2\" class=\"accordion-content\"\u003e\u003cp\u003ePterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural polyphenol compound primarily found in blueberries. Known for its higher bioavailability compared to other stilbene compounds, pterostilbene can significantly enhance the absorption efficiency of NMN. Studies have shown that pterostilbene’s bioavailability is approximately 80%, compared to only 20% for resveratrol, while offering many of the same beneficial biological regulatory effects as resveratrol.\u003c\/p\u003e\u003ch3\u003eKey Benefits and Functions of Pterostilbene:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Powerful Antioxidant Activity: Pterostilbene effectively eliminates reactive oxygen species (ROS) and reduces oxidative stress (OS), playing a crucial role in antioxidant defense. Its antioxidant properties are linked to benefits such as anti-cancer effects, neurological disease management, anti-inflammatory effects, vascular health improvement, and diabetes alleviation.\u003cbr\u003e• AMPK Activation: Pterostilbene activates AMPK, improving insulin resistance and promoting autophagy in the body. Enhanced autophagy activates SIRT2 proteins, which are essential for cell survival, DNA repair, antioxidant activity, and metabolic regulation.\u003cbr\u003e• Inflammation Mitigation in Osteoarthritis: Studies have shown that administering pterostilbene to mice with osteoarthritis reduced inflammatory mediators like COX-2, iNOS, and PGE2 induced by IL-1β. Additionally, mitochondrial and intracellular ROS production was significantly suppressed. Since COX-2 and PGE2 are key mediators of inflammation-induced osteoarthritis pain, these findings suggest that pterostilbene can effectively reduce low-level inflammation in cartilage cells.\u003c\/p\u003e\u003cp class=\"reference\"\u003eXue EX, Lin JP, Zhang Y, Sheng SR, Liu HX, Zhou YL, Xu H. Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Oncotarget. 2017 Jun 27;8(26):41988-42000. doi: 10.18632\/oncotarget.16716. PMID: 28410217; PMCID: PMC5522043.\u003c\/p\u003e\u003ch3\u003eNeuroprotective Effects:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Effective Blood-Brain Barrier Penetration: Pterostilbene effectively crosses the blood-brain barrier, helping to prevent neurodegenerative diseases. \u003cbr\u003e• Reduction of Oxidative Stress and Inflammation in Neural Tissue: It reduces oxidative stress and inflammation in neural tissue, enhancing cognitive function and memory. Studies have demonstrated that aged mice supplemented with pterostilbene showed improvements across various indicators, including cognitive abilities, behavior, memory tests, and mitochondrial function, which is the primary energy source for cells.\u003cbr\u003e• Enhancement of Learning and Memory Proteins: Pterostilbene supplementation increased the expression of PSD-95, a protein involved in learning and memory formation. This suggests its potential to alleviate functional impairments associated with Alzheimer’s disease.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/nmn_9bbe08e2-2c1b-4329-a239-0cd576a757ee.png?v=1732693258\" alt=\"NMN 이미지\" class=\"responsive-image\" \u003e\u003cp\u003e▲ Behavioral Assessment of Pterostilbene's Effects on Cognitive Function.\u003c\/p\u003e\u003cp\u003eIn (A), there was no difference between the two groups before treatment (p = 0.619), but after pterostilbene administration, the pterostilbene-treated group showed better performance compared to the control group (p = 0.013). In (B), the pterostilbene-treated group demonstrated a superior ability to distinguish objects compared to the control group (p = 0.003). In both (C) and (D), the pterostilbene-treated group outperformed the control group, successfully distinguishing between the two objects at both 1-hour and 24-hour intervals (p \u0026lt; 0.001 and p = 0.002, respectively).\u003c\/p\u003e\u003cp class=\"reference\"\u003eLa Spina M, Sansevero G, Biasutto L, Zoratti M, Peruzzo R, Berardi N, Sale A, Azzolini M. Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Cell Physiol Biochem. 2019;52(2):232-239. doi: 10.33594\/000000017. Epub 2019 Feb 28. PMID: 30816671.\u003c\/p\u003e\u003ch3\u003eCardiovascular Health:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Helps lower LDL cholesterol and triglyceride levels while increasing HDL cholesterol. \u003cbr\u003e• Prevents lipid oxidation, reducing the risk of atherosclerosis and cardiovascular diseases.\u003c\/p\u003e\u003ch3\u003eMetabolic Health and Diabetes Management:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Improves insulin sensitivity and regulates blood sugar levels. \u003cbr\u003e• Enhances lipid metabolism, supporting weight management.\u003c\/p\u003e\u003ch3\u003eAnticancer Potential:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Induces apoptosis (programmed cell death) in cancer cells and inhibits their proliferation. \u003cbr\u003e• Demonstrates efficacy against various cancer cell lines, including breast, colon, and lung cancers.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-3')\"\u003e THE BENEFIT OF NMN PTEROSTILBENE \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-3\" class=\"accordion-content\"\u003e\u003ch3\u003eSynergy Between NMN and Stilbene Compounds: Cellular Protection and Anti-Aging Effects\u003c\/h3\u003e\u003cp\u003eResearch indicates that combining NAD+ boosters like NMN with stilbene compounds amplifies their antioxidant and anti-aging effects.\u003c\/p\u003e\u003cp class=\"bullet\"\u003eCo-administration of NMN and Resveratrol: This combination resulted in higher NAD+ levels in the heart and skeletal muscles compared to NMN alone.\u003cbr\u003e• Co-administration of NMN and Ginsenosides: This pairing maximized NAD+ levels in brain, heart, kidney, and lung tissues, significantly surpassing the effects of NMN alone. \u003cbr\u003e• Co-administration of NR and Pterostilbene: In patients with acute kidney injury, this combination increased NAD+ levels by 40% and 90% after two doses, with consistent improvements observed throughout an 8-week trial period.\u003c\/p\u003e\u003cp\u003eThus, the combination of NMN with stilbene compounds represents an optimal approach for maximizing NAD+ levels and supporting longevity.\u003c\/p\u003e\u003cp class=\"reference\"\u003eSharma A, Chabloz S, Lapides RA, Roider E, Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023 Jan 14;15(2):445. DOI: 10.3390\/nu15020445. PMID: 36678315; PMCID: PMC9861325.\u003c\/p\u003e\u003ch3\u003eSynergy Between NMN and Pterostilbene: Cellular Protection and Anti-Aging Effects\u003c\/h3\u003e\u003cp\u003eThe synergy observed when NMN and Pterostilbene are taken together stems from their complementary mechanisms of cellular protection.\u003c\/p\u003e\u003cp class=\"bullet\"\u003e• Increased Cellular Energy Through NAD+ Supplementation: NMN boosts NAD+ levels, enhancing cellular energy, aiding cell regeneration, and promoting lifespan extension.\u003cbr\u003e• Antioxidant and Anti-inflammatory Effects: Pterostilbene reduces oxidative stress and suppresses inflammatory responses, preventing cellular damage and maintaining a healthy cellular environment.\u003c\/p\u003e\u003cp\u003eWhen combined, these mechanisms reinforce cellular resilience, protect against oxidative and inflammatory damage, and ensure sufficient cellular energy. This synergy results in enhanced fatigue recovery, chronic disease prevention, and amplified anti-aging effects.\u003c\/p\u003e\u003ch3\u003eStilbene Compounds: Pterostilbene vs. Resveratrol\u003c\/h3\u003e\u003cp\u003eWhen NMN is paired with Pterostilbene, the combined effects include NAD+ elevation for energy production and Pterostilbene's antioxidant properties, offering multifaceted cellular protection. This is because NMN converts into NAD+ within cells, serving as fuel for the longevity gene Sirtuin, while Pterostilbene acts as a Sirtuin activator. Research highlights that compared to Resveratrol, Pterostilbene is a safer and longer-lasting compound for delaying aging through sustained NAD+ presence in the body. Additionally: Conversion of Resveratrol to Pterostilbene: Resveratrol undergoes O-Methyltransferase action, replacing two hydroxyl hydrogen atoms with methyl groups to form Pterostilbene. Enhanced Retention and Absorption: Pterostilbene, being lipophilic, delays the excretion of NMN, allowing it to remain in the body longer. Furthermore, while Resveratrol has low oral bioavailability, Pterostilbene is absorbed over four times more efficiently. In conclusion, the combination of NMN and Pterostilbene not only boosts NAD+ levels but also amplifies the individual benefits of both compounds, making it the \"optimal anti-aging formula.\"\u003c\/p\u003e\u003cdiv class=\"image-row-1\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/e1de51b6590ceadab74cc5b197c3d6bb.png?v=1732757010\" alt=\"NMN 연구보고서 2\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-2\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003cimg src=\"https:\/\/store.img11.co.kr\/68904879\/bb9cec8b-2c7a-4b4a-9e17-17d585132392_1731543306010.png\" alt=\"제품 이미지 1\" \u003e \u003cimg src=\"https:\/\/store.img11.co.kr\/68904879\/5fc448ae-feb7-4362-96b3-9d6b9e5c224c_1731483835901.png\" alt=\"제품 이미지 2\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-3\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eDaily Intake\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e2 capsules : NMN(250mg) + Pterostilbene(250mg)\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003eNicotinamide Mononucleotide (NMN), Pterostilbene, Rice Bran Extract, and Vegetable Capsule.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eSuggested Use\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eTake 1 capsule daily before breakfast, or as directed by your physician.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eRecommended Age\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eAges 34 to 60+.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"supplement_fact_pannel\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/NMN_8e904412-7a2c-48a4-ad86-da26579d6ff1.png?v=1723192062\" alt=\"영양 성분표\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-4\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003ca href=\"https:\/\/unipass.customs.go.kr\/csp\/persIndex.do\" class=\"custom-button\" target=\"_blank\" rel=\"noopener\"\u003e개인통관고유부호 발급\u003c\/a\u003e \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/5_089577a1-048d-432e-935c-6962b5da3312.jpg?v=1716444829\" alt=\"구매 안내 이미지\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cstyle\u003e\n            \/* 공통 스타일 *\/\n            .tabcontent-cus {\n            text-align: left;\n            }\n            .responsive-image {\n            width: 100%;\n            max-width: 640px;\n            height: auto;\n            display: block;\n            margin: 20px auto;\n            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번째 아코디언 열기\n              document.addEventListener(\"DOMContentLoaded\", function () {\n              const accordionContents = document.querySelectorAll(\".accordion-content\");\n              const toggleIcons = document.querySelectorAll(\".toggle-icon\");\n              accordionContents.forEach((content, index) =\u003e {\n              content.classList.add(\"open\");\n              content.style.maxHeight = content.scrollHeight + \"px\";\n              if (toggleIcons[index]) {\n              toggleIcons[index].classList.add(\"rotate\");\n              }\n              });\n              });\n            \u003c\/script\u003e \u003c\/tc\u003e","brand":"ROKIT AMERICA","offers":[{"title":"Single","offer_id":40057081135177,"sku":"RA-FG-NMNPT1","price":51.55,"currency_code":"USD","in_stock":true},{"title":"3-Month Supply(29%OFF)","offer_id":40057081167945,"sku":"RA-FG-NMNPT2","price":129.19,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/nmn_1000.png?v=1781853718"},{"product_id":"fisetin","title":"\u003ctc\u003eFISETIN 60 capsules\u003c\/tc\u003e","description":"\u003ctc\u003e\u003cdiv id=\"tab-1\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"plus-tab-customizing\"\u003e\u003cdiv class=\"plus-tab-customizing-title\"\u003e\u003ch3\u003eWhat is the Fisetin?\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-container\"\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-1')\"\u003e WHAT IS THE FISETIN? \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-1\" class=\"accordion-content\"\u003e\u003cdiv class=\"image-row\"\u003e\u003cimg src=\"https:\/\/store.img11.co.kr\/68904879\/cd0f5f07-fbc9-4f63-8d20-619ad8a19774_1734932582679.jpg\" alt=\"1.jpg\" style=\"width: 800px; height: auto;\" \u003e\u003c\/div\u003e\u003cp\u003eFisetin, a polyphenolic compound in the flavonoid family, is abundant in strawberries, apples, persimmons, and lotus roots concentrations ranging from 0.1 to 160 μg\/g. Among these, strawberries contain the highest amount of fisetin, with 160 μg\/g. To consume 100 mg of fisetin, as provided in ROKIT America's product, one would need to eat approximately 52 strawberries.\u003c\/p\u003e\u003cp\u003eFisetin has gained significant attention for its diverse health benefits, including its ability to inhibit cellular senescence, reduce inflammation, protect the nervous system, and suppress tumor growth. These properties have led to extensive research into its therapeutic potential. Studies have demonstrated that fisetin could be an effective treatment for various conditions, such as Alzheimer’s disease, Parkinson’s disease, and traumatic brain injuries. It also shows promise in addressing chronic inflammatory and degenerative conditions like periodontitis, hypertrophic scars, and oxidative skin damage. Additionally, fisetin has been linked to improvements in metabolic and systemic disorders, including polycystic ovary syndrome (PCOS), osteoporosis, cardiovascular diseases, diabetic cardiomyopathy, high-fat diet-induced nephropathy, and hypercholesterolemia.\u003c\/p\u003e\u003cp\u003eFurthermore, fisetin is regarded as one of the most powerful senolytic compounds among polyphenols. Preclinical studies have shown that its senolytic properties can delay the aging process by eliminating senescent cells, making it a promising candidate for anti-aging and longevity-focused therapies. Through its wide range of biological mechanisms, fisetin stands out as a highly versatile compound with significant potential for disease treatment and overall health improvement.\u003c\/p\u003e\u003cp style=\"font-weight: bold; font-style: italic; color: blue; text-align: center;\"\u003e*Senolytic = Senescence + lytic\u003c\/p\u003e\u003ch3\u003eConsiderations When Consuming Fisetin\u003c\/h3\u003e\u003cp\u003eFisetin is a natural compound and is generally safe when consumed in typical food or supplement forms. However, high doses may occasionally cause digestive discomfort. As human studies on fisetin are still limited, individuals should monitor their health condition when consuming it in higher amounts. When taking fisetin supplements, it is advisable to adhere to the recommended dosage. Additionally, individuals who are pregnant or have specific medical conditions should consult a healthcare professional before use to ensure safety and avoid potential risks.\u003c\/p\u003e\u003cp\u003e\u0026nbsp;\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-2')\"\u003e FISEITN RESEARCH \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-2\" class=\"accordion-content\"\u003e\u003ch3\u003e1. Powerful Antioxidant and Anti-Inflammatory Properties\u003c\/h3\u003e\u003cp\u003eFisetin is a potent antioxidant that neutralizes harmful reactive oxygen species (ROS) in the body. ROS are generated due to factors such as stress, environmental pollution, and aging, and can cause damage to cells and DNA. Fisetin reduces oxidative damage and suppresses inflammation. This makes it valuable for preventing and treating various conditions.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Khan N., et al. (2013). “Fisetin: a dietary antioxidant for health promotion.” Antioxidants \u0026 Redox Signaling, 19(2), 151–162.\u003c\/p\u003e\u003ch3\u003e2. Senolytic Effects and Extended Healthspan\u003c\/h3\u003e\u003cp\u003eFisetin has garnered attention for its senolytic effects, which allow it to selectively eliminate senescent cells. Cellular senescence is a state in which cells no longer divide but instead secrete various pro-inflammatory factors associated with aging-related diseases and tissue damage.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Yousefzadeh M.J., et al. (2018). “Fisetin is a senotherapeutic that extends health and lifespan.” EBioMedicine, 36, 18–28.\u003c\/p\u003e\u003ch3\u003e3. Neuroprotection and Cognitive Function Improvement\u003c\/h3\u003e\u003cp\u003eFisetin has neuroprotective effects, making it beneficial for preventing neurodegenerative diseases such as Alzheimer’s disease. It protects nerve cells, reduces brain inflammation, and contributes to improved memory and learning abilities.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089\/ars.2012.4901. Epub 2012 Dec 18. PMID: 23121441; PMCID: PMC3689181.\u003c\/p\u003e\u003ch3\u003e4. Anticancer Effects\u003c\/h3\u003e\u003cp\u003eFisetin has demonstrated anticancer properties by inhibiting the growth of cancer cells and promoting their apoptosis (programmed cell death). Importantly, this apoptotic effect specifically targets cancer cells without affecting normal cells, indicating that fisetin selectively suppresses malignant cells.\u003c\/p\u003e\u003cp\u003eAnticancer effects of fisetin have been observed in various cancer types, including breast and prostate cancer. These effects are linked to fisetin’s ability to regulate oxidative stress and suppress inflammatory responses within cancer cells.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089\/ars.2012.4901. Epub 2012 Dec 18. PMID: 23121441; PMCID: PMC3689181.\u003c\/p\u003e\u003ch3\u003e5. Contributing to Cardiovascular Health\u003c\/h3\u003e\u003cp\u003eFisetin plays a significant role in supporting cardiovascular health. It helps prevent atherosclerosis by reducing inflammation and oxidative stress, while also protecting the vascular endothelium and contributing to blood pressure regulation. Studies have shown that fisetin reduces the production of inflammatory factors within blood vessels, thereby lowering the risk of cardiovascular diseases. Additionally, it has been reported to improve blood circulation, providing benefits for heart function and overall cardiovascular health. These properties position fisetin as a promising compound for maintaining a healthy cardiovascular system.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Rodius S, de Klein N, Jeanty C, Sánchez-Iranzo H, Crespo I, Ibberson M, Xenarios I, Dittmar G, Mercader N, Niclou SP, Azuaje F. Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity. Sci Rep. 2020 Feb 19;10(1):2896. doi: 10.1038\/s41598-020-59894-4. PMID: 32076073; PMCID: PMC7031222.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-3')\"\u003e THE BENEFIT OF ROKIT FISETIN \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-3\" class=\"accordion-content\"\u003e\u003ch3\u003eWhat Makes ROKIT America's Fisetin Unique?\u003c\/h3\u003e\u003ch3\u003e1. ROKIT America's Advanced Formulation for Maximum Efficacy\u003c\/h3\u003e\u003cp\u003eFisetin is a poorly water-soluble compound with a strong tendency to aggregate with lipids, making it less bioavailable when consumed on its own. Research has shown that standalone fisetin intake results in low absorption efficiency in the body. With a low solubility of 10.45 g\/mL and an oral bioavailability of only 44.1%, overcoming these limitations has been a key challenge. ROKIT America has developed an optimized formulation to enhance the bioavailability of fisetin, ensuring better absorption and effectiveness for consumers. This innovative approach sets their product apart in delivering the full potential of fisetin's health benefits.\u003c\/p\u003e\u003cp style=\"font-weight: bold;\"\u003e① Enhanced Absorption with Patented Ingredient BioPerine®\u003c\/p\u003e\u003cp\u003eBioPerine®, a patented ingredient, is proven to improve nutrient absorption by at least 30% with a recommended dosage of just 5 mL. ROKIT America has incorporated BioPerine® into its formulation and further reduced the particle size to enhance fisetin’s bioavailability significantly.\u003c\/p\u003e\u003cdiv class=\"image-row\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/2_56fa6f71-86c1-4c49-b8e4-53ea6344064e.gif?v=1734934930\" \u003e \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/3_8e81a66e-25e1-4fbf-9862-f933a78a3dd5.jpg?v=1734935071\" \u003e\u003c\/div\u003e\u003cp\u003eAs demonstrated in experimental studies, Rokit America’s scientifically optimized formulation and reduced particle size effectively increase the absorption rate of fisetin, ensuring maximum health benefits for consumers.\u003c\/p\u003e\u003cp style=\"font-weight: bold;\"\u003e② Combination of Fisetin with Ascorbic Acid (Vitamin C)\u003c\/p\u003e\u003cp\u003eROKIT America has included ascorbic acid (Vitamin C) in its formulation to enhance fisetin’s ability to inhibit cancer cell proliferation. Research has shown that the combination of fisetin and Vitamin C can suppress cancer cell growth by up to 61%. This synergistic effect underscores the added benefits of pairing fisetin with Vitamin C for maximum efficacy in combating cancer-related concerns.\u003c\/p\u003e\u003ch3\u003e2. 99% High-Purity Fisetin\u003c\/h3\u003e\u003ch3\u003e\u003c\/h3\u003e\u003cp\u003eROKIT America uses a fisetin raw material with an exceptional purity level of 99%, as verified in June 2024. This makes it the highest-purity fisetin among existing products.\u003c\/p\u003e\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/4_84dde46b-9d98-48eb-8c42-6c2926271688.jpg?v=1734935251\" alt=\"이미지\" \u003e\u003c\/div\u003e\u003cp style=\"text-align: center;\"\u003e▲ Certified Laboratories Purity Test Results\u003c\/p\u003e\u003cp\u003e‘High purity signifies that impurities and unnecessary substances have been effectively removed, resulting in a highly refined and concentrated product. Choosing a high-purity supplement ensures that a greater amount of the desired active ingredient is consumed, even at the same dosage. Additionally, higher purity minimizes unpleasant odors and reduces the risk of gastrointestinal discomfort. When selecting nutritional supplements, the importance of purity cannot be overstated, and Rokit America's commitment to using 99% pure fisetin sets a new standard for quality and effectiveness.\u003c\/p\u003e\u003ch3\u003e3. Assay Above 98% Fisetin\u003c\/h3\u003e\u003cp\u003eUnlike other products, ROKIT America’s fisetin not only boasts exceptional purity but also uses raw materials with an assay exceeding 98%.\u003c\/p\u003e\u003cp\u003eThe assay is a key indicator of the concentration of a specific active ingredient in a product. A higher assay signifies a higher concentration of the effective component, allowing for greater efficacy even with the same dosage. This means that consumers can achieve optimal results with smaller amounts, making it a cost-efficient choice in the long run. When selecting a supplement, considering the \u003cstrong\u003eassay value\u003c\/strong\u003e is crucial to ensure both effectiveness and value for your investment. ROKIT America sets itself apart by prioritizing high assay standards in its fisetin formulation.\u003c\/p\u003e\u003cdiv style=\"border: 1px solid #000; padding: 20px; background-color: transparent; text-align: left; margin-bottom: 40px;\"\u003e\u003ch3 style=\"text-align: center; font-weight: bold; margin-bottom: 20px;\"\u003e*Purity vs Assay\u003c\/h3\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u003cbr\u003eThis measures how free a specific ingredient is from inpurities or unwanted substances. For instance, a product with 99% purity indicates that the ingredient is almost completely clean and refined, with minimal contamination or extraneous materials.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAssay:\u003c\/strong\u003e \u003cbr\u003eThis measures how much of the active ingredient is actually present in the product. For example, if a capsule claims to contain 500mg of an active ingredient, an assay test verifies whether this amount is accurate.\u003c\/p\u003e\u003cp\u003eIn summary, purity confirms \"how clean the ingredient is,\" while assay ensures \"how much of the ingredient is actually included in the product.\" Both are essential indicators for assessing the quality and effectiveness of supplements.\u003c\/p\u003e\u003c\/div\u003e\u003ch3\u003e4. Plant-Based Capsules with No Chemical Additives\u003c\/h3\u003e\u003cp\u003eROKIT America’s fisetin is delivered in plant-based capsules, designed to be gentle on the body and dissolve more effectively than animal-based capsules. This ensures a smoother and more efficient delivery of the active ingredient, while avoiding the use of synthetic chemical additives.\u003c\/p\u003e\u003ch3\u003e5. Safe Manufacturing and Rigorous Quality Control\u003c\/h3\u003e\u003cp\u003eROKIT America’s fisetin is produced under strict quality control in FDA-approved manufacturing facilities in the United States. This guarantees a safe and reliable product that consumers can trust for their health and wellness needs.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference:\u003cbr\u003e[1] Szymczak J, Cielecka-Piontek J. Fisetin-In Search of Better Bioavailability-From Macro to Nano Modifications: A Review. Int J Mol Sci. 2023 Sep 15;24(18):14158. doi: 10.3390\/ijms241814158. PMID: 37762460; PMCID: PMC10532335.\u003cbr\u003e[2] Mehta P, Pawar A, Mahadik K, Bothiraja C. Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. Biomed Pharmacother. 2018 Oct;106:1282-1291. doi: 10.1016\/j.biopha.2018.07.079. Epub 2018 Jul 20. PMID: 30119198.\u003cbr\u003e[3] Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E Jr. Ascorbic acid-enhanced antiproliferative effect of flavonoids on squamous cell carcinoma in vitro. Anticancer Drugs. 1993 Feb;4(1):91-6. doi: 10.1097\/00001813-199302000-00012. PMID: 8457720.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-2\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/Rokit-America-Inc-_240606.jpg?v=1723424998\" alt=\"제품 이미지 1\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-3\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eDaily Intake\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e2 capsules : Fisetin (100 mg), Vitamin C (50 mg), and BioPerine® (5 mg).\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003eFisetin, Vitamin C, BioPerine® (Black Pepper Extract), Soluble Dietary Fiber, MCT Powder (from Coconut Oil), Vegetable Capsule, and Rice Bran Extract.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eSuggested Use\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eTake 2 capsules daily after meals, or as directed by your physician.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eRecommended Age\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eAges 34 to 60+.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"supplement_fact_pannel\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/FISETIN_54e2beff-b481-4dfb-b8bb-091e6da4aec3.png?v=1723178254\" alt=\"영양 성분표\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-4\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003ca 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16px;\n                color: #000;\n                }\n                .accordion-content h3 {\n                font-size: 40px;\n                }\n                .accordion-content p {\n                font-size: 20px;\n                line-height: 1.6;\n                }\n                .bullet::before {\n                font-size: 14px;\n                left: -15px;\n                }\n                .reference {\n                font-size: 9px !important;\n                }\n                .custom-button {\n                padding: 8px 16px;\n                font-size: 14px;\n                }\n                .image-row img {\n                flex: 1 1 45%;\n                max-width: 45%;\n                }\n                .plus-tab-customizing-title h3 {\n                font-size: 24px;\n                }\n                }\n                @media (max-width: 480px) {\n                .accordion-button {\n                font-size: 14px;\n                color: #000;\n                }\n                .accordion-content h3 {\n                font-size: 14px;\n                }\n                .accordion-content p {\n                font-size: 8px;\n                line-height: 1.6;\n                }\n                .bullet::before {\n                font-size: 12px;\n                left: -12px;\n                }\n                .reference {\n                font-size: 8px !important;\n                }\n                .custom-button {\n                padding: 6px 12px;\n                font-size: 12px;\n                }\n                .image-row img {\n                flex: 1 1 100%;\n                max-width: 100%;\n                }\n                .plus-tab-customizing-title h3 {\n                font-size: 20px;\n                }\n                }\n              \u003c\/style\u003e\u003cscript\u003e\n                  function toggleAccordion(event, contentId) {\n                  const content = document.getElementById(contentId);\n                  const button = event.currentTarget;\n                  \/\/ 열기 상태 확인\n                  const isOpen = content.classList.contains(\"open\");\n                  \/\/ 클릭한 항목 열기\/닫기\n                  if (!isOpen) {\n                  content.classList.add(\"open\");\n                  content.style.maxHeight = content.scrollHeight + \"px\";\n                  button.querySelector(\".toggle-icon\").classList.add(\"rotate\");\n                  } else {\n                  content.classList.remove(\"open\");\n                  content.style.maxHeight = \"0\";\n                  button.querySelector(\".toggle-icon\").classList.remove(\"rotate\");\n                  }\n                  }\n                  \/\/ 페이지 로드 시 첫 번째 아코디언 열기\n                  document.addEventListener(\"DOMContentLoaded\", function () {\n                  const accordionContents = document.querySelectorAll(\".accordion-content\");\n                  const toggleIcons = document.querySelectorAll(\".toggle-icon\");\n                  accordionContents.forEach((content, index) =\u003e {\n                  content.classList.add(\"open\");\n                  content.style.maxHeight = content.scrollHeight + \"px\";\n                  if (toggleIcons[index]) {\n                  toggleIcons[index].classList.add(\"rotate\");\n                  }\n                  });\n                  });\n                \u003c\/script\u003e \u003c\/tc\u003e","brand":"ROKIT AMERICA","offers":[{"title":"Single","offer_id":40057082249289,"sku":"RA-FG-FSC1","price":36.43,"currency_code":"USD","in_stock":true},{"title":"3-Month Supply(20%OFF)","offer_id":40057082314825,"sku":"RA-FG-FSC2","price":97.15,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/fisetin_1000.png?v=1781855545"},{"product_id":"stress-care","title":"\u003ctc\u003eSTRESS CARE\n\u003c\/tc\u003e","description":"\u003ctc\u003e\u003cdiv id=\"tab-1\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"plus-tab-customizing\"\u003e\u003cdiv class=\"plus-tab-customizing-title\"\u003e\u003ch3\u003eWhat is the STRESS CARE?\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-container\"\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-1')\"\u003e WHAT IS STRESS CARE? \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-1\" class=\"accordion-content\"\u003e\u003ch3\u003e1. Physical Comfort\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Vitamin B12: Essential for energy production and maintaining nervous system health. A deficiency can result in fatigue and nerve damage.\u003c\/p\u003e\u003ch3\u003e2. Mineral Ingredients\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• \u003cb\u003eIodine:\u003c\/b\u003e Supports thyroid function, energy metabolism, and bodily balance. Regulates metabolic activities through hormone production.\u003cbr\u003e• \u003cb\u003eManganese:\u003c\/b\u003e Contributes to antioxidant activity, bone health, and supports nervous system function.\u003cbr\u003e• \u003cb\u003eCopper:\u003c\/b\u003e Aids in collagen formation, boosts immunity, and provides antioxidant benefits. It is a vital mineral for enzyme activation.\u003cbr\u003e• \u003cb\u003eSelenium:\u003c\/b\u003e Helps with antioxidant activity and enhances immune function.\u003cbr\u003e• \u003cb\u003eZinc:\u003c\/b\u003e Promotes immune function, wound healing, and improves skin health. It plays a critical role in DNA synthesis and cellular repair processes.\u003cbr\u003e• \u003cb\u003eKelp and North Sea Coastal Seaweed:\u003c\/b\u003e Rich in minerals and antioxidants, they help detoxify the body and alleviate stress. Additionally, they provide dietary fiber to support digestive health.\u003c\/p\u003e\u003ch3\u003e3. Ingredients for Mental Comfort\u003c\/h3\u003e\u003cp\u003e• \u003cb\u003eAshwagandha:\u003c\/b\u003e Effective in reducing stress and improving sleep quality.\u003cbr\u003e• \u003cb\u003eSchisandra:\u003c\/b\u003e Offers antioxidant effects and aids in fatigue recovery and immune enhancement.\u003cbr\u003e• \u003cb\u003eEleuthero (Siberian Ginseng):\u003c\/b\u003e Increases resistance to stress and helps combat stress while boosting energy and reducing fatigue.\u003c\/p\u003e\u003cp\u003eTogether, these ingredients enhance overall quality of life. Their complementary effects help alleviate stress and improve sleep, making them highly relevant to the demands of modern living.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-2')\"\u003e WHAT IS ASHWAGANDHA? \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-2\" class=\"accordion-content\"\u003e\u003cp\u003eAshwagandha, a herb with a long history in India’s traditional Ayurvedic medicine, is commonly referred to as \"Indian ginseng.\" It is renowned for its benefits in stress relief, sleep improvement, and immune system enhancement. Recent scientific studies have validated its effectiveness, making Ashwagandha particularly notable for addressing modern challenges such as stress and sleep disorders.\u003c\/p\u003e\u003ch3\u003eKey Benefits of Ashwagandha:\u003c\/h3\u003e\u003cp\u003e① Stress and Anxiety Reduction and Mental Calmness: Ashwagandha helps regulate the HPA axis (Hypothalamic-Pituitary-Adrenal Axis), improving the body’s stress response.\u003c\/p\u003e\u003cp\u003e* HPA Axis: The HPA axis is a biochemical system that regulates hormone interactions between the hypothalamus, pituitary gland, and adrenal cortex, forming a critical part of the neuroendocrine system. By modulating this axis, Ashwagandha can effectively alleviate stress and anxiety, promoting mental stability and resilience.\u003c\/p\u003e\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/2025-01-06_4.51.57.png?v=1736149994\" style=\"max-width: 1000px; width: 100%; height: auto;\" \u003e\u003c\/div\u003e\u003cp\u003eStudies have shown that women who consumed Ashwagandha extract experienced a statistically significant 25% reduction in cortisol levels. Additionally, an 8% reduction in DHEA-S levels was observed in the Ashwagandha group. Lastly, testosterone levels in the Ashwagandha group were found to have increased by 11% over time, also statistically significant. These results highlight the potential of Ashwagandha for hormonal balance and stress regulation.\u003c\/p\u003e\u003cp\u003e*Cortisol, DHEA-S, and testosterone are steroid hormones are key steroid hormones involved in stress and energy regulation.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097\/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.\u003c\/p\u003e\u003cp\u003e② Improved Sleep Quality: Ashwagandha has proven effective in enhancing sleep quality. According to research, individuals who consumed Ashwagandha reported a 72% increase in self-perceived sleep quality, compared to only a 29% increase in the placebo group. This improvement was also reflected in significant enhancements in sleep efficiency and total sleep duration, indicating its potential as a natural sleep aid.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020 Aug;72:28-36. doi: 10.1016\/j.sleep.2020.03.012. Epub 2020 Mar 21. PMID: 32540634.\u003c\/p\u003e\u003cp\u003e③ Energy Boost and Fatigue Reduction: Ashwagandha enhances physical strength and endurance while positively impacting individuals experiencing chronic fatigue. It is particularly known for accelerating post-exercise recovery and reducing muscle fatigue, making it an effective natural remedy for improving overall energy levels and stamina.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Mikulska P, Malinowska M, Ignacyk M, Szustowski P, Nowak J, Pesta K, Szeląg M, Szklanny D, Judasz E, Kaczmarek G, Ejiohuo OP, Paczkowska-Walendowska M, Gościniak A, Cielecka-Piontek J. Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics. 2023 Mar 24;15(4):1057. doi: 10.3390\/pharmaceutics15041057. PMID: 37111543; PMCID: PMC10147008.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-3')\"\u003e ABOUT ROKIT STRESSCARE \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-3\" class=\"accordion-content\"\u003e\u003ch3\u003eDosage and Consumption Guidelines:\u003c\/h3\u003e\u003cp\u003e① Plant-Based Pectin for Healthier Gummy Texture: Unlike animal-based gelatin, Stress Care gummies are made with plant-based pectin, which gives them a soft texture but may adhere slightly to the teeth.\u003cbr\u003e② Chewing Recommended: It is advised to chew the gummies rather than swallowing them directly for better absorption.\u003cbr\u003e③ Timing of Intake: For stress management: Take 2 gummies at any desired time of the day. For better sleep: Take 2 gummies 30 minutes before bedtime.\u003c\/p\u003e\u003ch3\u003eTHE BENEFIT OF ROKIT STRESSCARE\u003c\/h3\u003e\u003cp\u003e\u003cb\u003e① Optimal Blend Ratio:\u003c\/b\u003e Each ingredient is blended at an optimal ratio based on scientific research, maximizing the individual benefits and synergistic effects. This custom-designed supplement combines ingredients that enhance stress relief, reduce fatigue, and improve sleep quality when taken together.\u003cbr\u003e\u003cb\u003e② Plant-Based Pectin Gummies:\u003c\/b\u003e Made with pectin, a soluble dietary fiber, these gummies may positively impact digestive health while catering to those who prefer vegan-friendly products.\u003cbr\u003e\u003cb\u003e③ Guaranteed Safety and Research-Based Production:\u003c\/b\u003e Produced using verified ingredients with rigorous quality control at every stage. Manufactured in the U.S. at NSF GMP-certified facilities, ensuring trustworthy and reliable quality.\u003cbr\u003e④ \u003cb\u003eVegan, Non-GMO, and Free from Heavy Metals\u003c\/b\u003e\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-2\" class=\"tabcontent-cus\"\u003e\u003c\/div\u003e\u003cdiv id=\"tab-3\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eDaily Intake\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003e2 Gummies\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003eVitamin B12, Iodine, Zinc, Selenium, Copper, Manganese, Ashwagandha, Schisandra, Siberian Ginseng (Eleuthero), North Atlantic Seaweed, L-Tyrosine, Kelp, Sugar, and Sodium.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eSuggested Use\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003eTake 2 gummies daily before sleep, or as directed by your physician.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eRecommended Age\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eAges 18 to 60+.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"supplement_fact_pannel\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/STRESS_CARE.png?v=1723192062\" alt=\"영양 성분표\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-4\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003ca href=\"https:\/\/unipass.customs.go.kr\/csp\/persIndex.do\" class=\"custom-button\" target=\"_blank\" rel=\"noopener\"\u003e개인통관고유부호 발급\u003c\/a\u003e \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/5_089577a1-048d-432e-935c-6962b5da3312.jpg?v=1716444829\" alt=\"구매 안내 이미지\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cstyle\u003e\n          \/* 공통 스타일 *\/\n          .tabcontent-cus {\n          text-align: left;\n          }\n          .responsive-image {\n          width: 100%;\n          max-width: 640px;\n          height: auto;\n          display: block;\n          margin: 20px auto;\n          }\n          .plus-tab-customizing-title h3 {\n          font-size: 48px;\n          margin-bottom: 20px;\n          }\n          .accordion-container {\n          border: 1px solid #ccc;\n          border-radius: 5px;\n          width: 100%;\n          margin: 20px auto;\n          background: #f9f9f9;\n          }\n          .accordion-item {\n          border-bottom: 1px solid #e5e5e5;\n          }\n          .accordion-button {\n          width: 100%;\n          padding: 15px 20px;\n          text-align: left;\n          background: none;\n          border: none;\n          outline: none;\n          font-size: 30px;\n          font-weight: bold;\n          cursor: pointer;\n          display: flex;\n          justify-content: space-between;\n          align-items: center;\n          }\n          \/* 모바일 전용 스타일 *\/\n          @media (max-width: 768px) {\n          .accordion-button {\n          padding: 5px 15px; \/* 모바일에서 패딩 줄이기 *\/\n          font-size: 30px;\n          }\n          }\n          .accordion-button:hover {\n          background: #eee;\n          }\n          .accordion-content {\n          padding: 0 20px;\n          max-height: 0;\n          overflow: hidden;\n          transition: max-height 0.3s ease;\n          background: #fff;\n          }\n          \/* 모바일 전용 스타일 *\/\n          @media (max-width: 768px) {\n          .accordion-content {\n          padding: 0; \/* 모바일에서 패딩 제거 *\/\n          }\n          }\n          .accordion-content.open {\n          padding: 15px 20px;\n          max-height: 5000px;\n          }\n          .accordion-content h3 {\n          font-size: 30px;\n          margin-bottom: 30px;\n          }\n          .accordion-content p {\n          font-size: 18px;\n          line-height: 1.8;\n          margin-bottom: 30px;\n          }\n          \/* 모바일 전용 스타일 *\/\n          @media (max-width: 768px) {\n          .accordion-content p {\n          font-size: 24px; \/* 모바일에서 폰트 크기 조정 *\/\n          }\n          }\n          .bullet {\n          position: relative;\n          margin-left: 20px;\n          }\n          .bullet::before {\n          position: absolute;\n          left: -20px;\n          font-size: 32px;\n          line-height: 1.8;\n          }\n          .reference {\n          color: #b7b7b7;\n          font-size: 18px !important;\n          font-style: italic;\n          }\n          .toggle-icon {\n          font-size: 40px;\n          transition: transform 0.3s;\n          }\n          \/* 모바일 전용 스타일 *\/\n          @media (max-width: 768px) {\n          .toggle-icon {\n          font-size: 28px; \/* 모바일에서 폰트 크기 조정 *\/\n          }\n          }\n          .toggle-icon.rotate {\n          transform: rotate(45deg);\n          }\n          .button-container {\n          text-align: center;\n          margin: 40px 0;\n          display: flex;\n          flex-direction: column;\n          align-items: center;\n          }\n          .custom-button {\n          display: block;\n          width: 80%;\n          padding: 20px 10px;\n          border: 1px solid #cfcfcf;\n          border-radius: 50px;\n          background-color: #f4f4f4;\n          color: #333;\n          font-size: 26px;\n          font-weight: bold;\n          text-decoration: none;\n          margin-bottom: 20px;\n          text-align: center;\n          transition: background-color 0.3s ease, color 0.3s ease;\n          }\n          \/* 모바일 전용 스타일 *\/\n          @media (max-width: 768px) {\n          .custom-button {\n          width: 90%; \/* 모바일에서 너비 변경 *\/\n          margin-bottom: 5px; \/* 모바일에서 margin-bottom 변경 *\/\n          }\n          }\n          .custom-button:hover {\n          background-color: #7a7a7a;\n          color: #fff;\n          }\n          .image-container {\n          position: relative;\n          text-align: center;\n          display: flex;\n          flex-direction: column;\n          align-items: center;\n          }\n          .image-container img {\n          max-width: 100%;\n          height: auto;\n          margin-bottom: 20px;\n          }\n          .image-row {\n          display: flex;\n          justify-content: center;\n          flex-wrap: wrap;\n          gap: 20px;\n          margin: 40px 0;\n          }\n          .image-row img {\n          flex: 1 1 30%;\n          max-width: 30%;\n          }\n          .test-report-image {\n          box-shadow: 0 4px 6px rgba(0, 0, 0, 0.1);\n          }\n          .image-row-1 {\n          display: flex;\n          justify-content: center;\n          flex-wrap: wrap;\n          gap: 20px;\n          margin: 40px 0;\n          }\n          .image-row-1 img {\n          max-width: 80%;\n          }\n          .pdp_des {\n          margin-bottom: 20px;\n          }\n          .pdp_des .tit {\n          font-weight: bold;\n          margin-bottom: 5px;\n          }\n          .supplement_fact_pannel img {\n          width: 100%;\n          height: auto;\n          margin-top: 20px;\n          }\n          .red-text {\n          color: red;\n          }\n          \/* 반응형 디자인 *\/\n          @media (max-width: 768px) {\n          .accordion-button {\n          font-size: 16px;\n          color: #000;\n          }\n          .accordion-content h3 {\n          font-size: 40px;\n          }\n          .accordion-content p {\n          font-size: 20px;\n          line-height: 1.6;\n          }\n          .bullet::before {\n          font-size: 14px;\n          left: -15px;\n          }\n          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() {\n          const accordionContents = document.querySelectorAll(\".accordion-content\");\n          const toggleIcons = document.querySelectorAll(\".toggle-icon\");\n          accordionContents.forEach((content, index) =\u003e {\n          content.classList.add(\"open\");\n          content.style.maxHeight = content.scrollHeight + \"px\";\n          if (toggleIcons[index]) {\n          toggleIcons[index].classList.add(\"rotate\");\n          }\n          });\n          });\n        \u003c\/script\u003e \u003c\/tc\u003e","brand":"ROKIT AMERICA","offers":[{"title":"Single","offer_id":40057244418121,"sku":"RA-FG-SC1","price":19.08,"currency_code":"USD","in_stock":false},{"title":"3-Month Supply","offer_id":40057244450889,"sku":"RA-FG-SC2","price":57.24,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/stresscare_1000_32eedb53-1aff-4ea9-a2dd-9bd87c68dd7b.png?v=1781856032"},{"product_id":"women-plus","title":"\u003ctc\u003eWOMEN PLUS 60 capsules\n\u003c\/tc\u003e","description":"\u003ctc\u003e\u003cdiv id=\"tab-1\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"plus-tab-customizing\"\u003e\u003cdiv class=\"plus-tab-customizing-title\"\u003e\u003ch3\u003eWhat is the WOMENPLUS?\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-container\"\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-1')\"\u003e WHAT IS WOMENPLUS? \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-1\" class=\"accordion-content\"\u003e\u003cp\u003eROKIT America’s WOMEN PLUS combines three scientifically formulated key ingredients—Trans-Resveratrol, Quercetin Dihydrate, and Active Folate—to provide various health benefits such as enhanced immunity, antioxidant support, and improved brain health.\u003c\/p\u003e\u003ch3\u003e(1) Trans-Resveratrol\u003c\/h3\u003e\u003cp\u003eResveratrol is a polyphenolic antioxidant compound found in grape skins, blueberries, and peanuts, known for its antioxidant, anti-inflammatory, and anti-aging effects.\u003c\/p\u003e\u003cp\u003eWOMEN PLUS utilizes Trans-Resveratrol, a more stable and bioavailable form of resveratrol, instead of the commonly used cis-resveratrol.\u003c\/p\u003e\u003cp\u003e[Structural Differences]\u003c\/p\u003e\u003cp\u003eThe main structural difference between trans-resveratrol and cis-resveratrol lies in the position of hydroxyl groups:\u003c\/p\u003e\u003cp\u003e- Trans-Resveratrol: Hydroxyl groups are positioned on opposite sides of the molecule.\u003cbr\u003e- Cis-Resveratrol: Hydroxyl groups are positioned on the same side of the molecule.\u003c\/p\u003e\u003cp\u003e(Images of molecular structures can be included here for clarity.)\u003c\/p\u003e\u003cp\u003eThis structural difference gives trans-resveratrol a more stable molecular configuration, resulting in the following advantages:\u003c\/p\u003e\u003cp\u003e① Higher Bioavailability: Due to its structural stability, trans-resveratrol remains active in the body for a longer duration and is more effectively utilized.\u003cbr\u003e② Enhanced Antioxidant Effect: The structural stability of trans-resveratrol enables it to combat oxidative stress more effectively than cis-resveratrol.\u003cbr\u003e③ Increased Efficacy: Improved bioavailability allows for similar benefits at lower doses compared to higher doses of standard resveratrol.\u003c\/p\u003e\u003ch3\u003e(2) Quercetin Dihydrate\u003c\/h3\u003e\u003cp\u003eQuercetin is a flavonoid antioxidant compound commonly found in various fruits and vegetables, such as onions, apples, berries, green tea, and red wine. Its key benefits include antioxidant activity, anti-inflammatory effects, immune support, cardiovascular health improvement, and allergy suppression.\u003c\/p\u003e\u003cp\u003eIn ROKIT America’s WOMEN PLUS, quercetin is formulated as dihydrate quercetin, a superior form that enhances solubility and bioavailability, making it more effective than standard quercetin.\u003c\/p\u003e\u003cp\u003e① Enhanced Solubility: Quercetin dihydrate has two water molecules attached to each quercetin molecule, allowing it to dissolve more easily in water-based solutions.\u003cbr\u003e② Increased Bioavailability: Improved solubility enables the body to absorb and utilize quercetin more efficiently, meaning a greater proportion of the ingested quercetin is actively used by the body.\u003cbr\u003e③ Improved Stability: The bonded water molecules help protect quercetin from damage and oxidation, ensuring its effectiveness over time.\u003c\/p\u003e\u003ch3\u003e(3) 5-Methyltetrahydrofolate\u003c\/h3\u003e\u003cp\u003eFolate, abundant in leafy green vegetables like broccoli, spinach, and avocados, is a water-soluble vitamin essential for cell growth and DNA synthesis, particularly crucial for fetal development during pregnancy.\u003c\/p\u003e\u003cp\u003eWhile regular folate needs to be converted into its active form, 5-Methyltetrahydrofolate (5-MTHF), to be utilized by the body, this conversion may not function efficiently in individuals with issues in folate metabolism. Active folate eliminates this challenge by being directly available for use.\u003c\/p\u003e\u003cp\u003e① Immediate Usability: Active folate is in a ready-to-use form, bypassing the conversion process required by regular folate, allowing for quicker absorption and utilization.\u003cbr\u003e② Resolves Folate Metabolism Issues: For individuals with genetic variations in the MTHFR enzyme, which hinders the efficient utilization of regular folate, active folate provides a direct solution.\u003cbr\u003e③ Cardiovascular Health Support: Active folate effectively reduces homocysteine levels, a risk factor for cardiovascular diseases, providing better health benefits with lower doses.\u003cbr\u003e④ Prevents Vitamin B12 Deficiency Masking: Unlike regular folate, active folate does not mask symptoms of vitamin B12 deficiency, ensuring safer supplementation.\u003c\/p\u003e\u003cp\u003eBy being directly absorbable and functional, active folate works synergistically with Trans-Resveratrol and Quercetin Dihydrate, enhancing overall health benefits such as improved cardiovascular health, antioxidant effects, and cellular protection.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-2')\"\u003e WOMENPLUS RESEARCH \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-2\" class=\"accordion-content\"\u003e\u003ch3\u003e(1) Benefits of Trans-Resveratrol\u003c\/h3\u003e\u003cp\u003e• Antioxidant Effect\u003c\/p\u003e\u003cp\u003eMechanism: Reactive oxygen species (ROS) are naturally produced in the body but can accumulate excessively, causing cellular damage and accelerating aging. Trans-resveratrol effectively removes these ROS, reducing oxidative stress.\u003c\/p\u003e\u003cp\u003eResearch Evidence: Studies show that resveratrol increases the activity of antioxidant enzymes such as SOD (superoxide dismutase) and CAT (catalase), contributing to anti-aging, preventing cellular damage, and reducing skin aging.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: 헬스미디어, Resveratrol의 항산화 효과https:\/\/www.healthmedia.co.kr\/news\/articleView.html?idxno=50857\u003c\/p\u003e\u003cp\u003e• Anti-Inflammatory Effect\u003c\/p\u003e\u003cp\u003eMechanism: Chronic inflammation is a major contributor to diseases like cardiovascular conditions, diabetes, and obesity. Trans-resveratrol inhibits inflammatory pathways such as the NF-κB pathway, reducing the production of inflammatory mediators like TNF-α and IL-6. Benefits: This action supports the management of arthritis, chronic inflammation, and metabolic syndrome.\u003c\/p\u003e\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/ijms-19-01812-g001.jpg?v=1736169048\" style=\"width: 60%; height: auto;\" \u003e\u003c\/div\u003e\u003cp\u003eDotted arrows indicate mechanisms not fully understood, while solid arrows indicate activation or inhibition pathways. Resveratrol regulates critical signaling pathways, directly and indirectly protecting cells from inflammation.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: de Sá Coutinho D, Pacheco MT, Frozza RL, Bernardi A. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. Int J Mol Sci. 2018 Jun 20;19(6):1812. doi: 10.3390\/ijms19061812. PMID: 29925765; PMCID: PMC6032205.\u003c\/p\u003e\u003cp\u003e• Cardiovascular Health\u003c\/p\u003e\u003cp\u003eMechanism: Trans-resveratrol plays a crucial role in preventing cardiovascular diseases by promoting blood vessel dilation, improving blood flow, regulating blood pressure, and reducing LDL cholesterol levels. Research Evidence: Studies indicate that trans-resveratrol reduces oxidative stress in vascular endothelial cells, promoting blood vessel dilation and enhancing circulation.\u003c\/p\u003e\u003cp class=\"reference\"\u003eBonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016 May 2;8(5):250. doi: 10.3390\/nu8050250. PMID: 27144581; PMCID: PMC4882663.\u003c\/p\u003e\u003cp\u003e• Neuroprotection\u003c\/p\u003e\u003cp\u003eBenefits: Trans-resveratrol protects brain cells and supports neurological health, helping to prevent neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Mechanism: Resveratrol increases levels of BDNF (Brain-Derived Neurotrophic Factor), improving memory and learning ability.\u003c\/p\u003e\u003cp\u003e• Anti-Cancer Effect\u003c\/p\u003e\u003cp\u003eMechanism: Trans-resveratrol induces apoptosis (programmed cell death) and inhibits the proliferation of cancer cells. Research Focus: It has shown inhibitory effects on breast cancer, prostate cancer, and colon cancer by suppressing cancer cell growth and regulating the cell cycle to trigger apoptosis.\u003c\/p\u003e\u003ch3\u003e(2) Benefits of Quercetin Dihydrate\u003c\/h3\u003e\u003cp\u003e• Antioxidant Effect\u003c\/p\u003e\u003cp\u003eMechanism: Quercetin has strong antioxidant properties that eliminate reactive oxygen species (ROS) and reduce oxidative stress. By increasing the activity of antioxidant enzymes like SOD (superoxide dismutase), quercetin helps delay cellular aging.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008 May 13;585(2-3):325-37. doi: 10.1016\/j.ejphar.2008.03.008. Epub 2008 Mar 18. PMID: 18417116.\u003c\/p\u003e\u003cp\u003e• Anti-Inflammatory Effect\u003c\/p\u003e\u003cp\u003eMechanism: Quercetin regulates the immune system, enhancing the response against viral infections. It inhibits inflammatory pathways, including the NF-κB pathway, blocking the production of inflammatory mediators like TNF-α and IL-6, thereby alleviating symptoms of chronic inflammation-related diseases such as arthritis, obesity, and cardiovascular conditions.\u003c\/p\u003e\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/2025-01-06_10.21.14.png?v=1736169694\" style=\"width: 60%; height: auto;\" \u003e\u003c\/div\u003e\u003cp\u003eModel Explanation: Quercetin prevents TNF-α-induced activation of inflammatory genes and proteins, indirectly countering inflammation by antagonizing transcription factors like NF-κB and AP-1.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y. Quercetin, Inflammation and Immunity. Nutrients. 2016 Mar 15;8(3):167. doi: 10.3390\/nu8030167. PMID: 26999194; PMCID: PMC4808895.\u003c\/p\u003e\u003cp\u003e• Immune Support\u003c\/p\u003e\u003cp\u003eMechanism: Quercetin enhances the activity of immune cells like T cells and B cells, boosting the body’s defense against viruses and bacteria. Research Evidence: Quercetin has been shown to inhibit the replication of cold and flu viruses, reducing the spread of infections and mitigating resistance to antiviral treatments.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: 퀘르세틴과 비타민 D는 코로나바이러스에 대항하는 아군일까요? https:\/\/korean.mercola.com\/sites\/articles\/archive\/2020\/03\/27\/%ED%80%98%EB%A5%B4%EC%84%B8%ED%8B%B4-%EB%B9%84%ED%83%80%EB%AF%BC-d-%EC%BD%94%EB%A1%9C%EB%82%98%EB%B0%94%EC%9D%B4%EB%9F%AC%EC%8A%A4-%EC%98%88%EB%B0%A9.aspx\u003c\/p\u003e\u003cp\u003e• Cardiovascular Health\u003c\/p\u003e\u003cp\u003eMechanism: Quercetin reduces LDL cholesterol (bad cholesterol) and promotes vasodilation. It stimulates the production of nitric oxide (NO), improving blood flow and preventing the oxidation of LDL cholesterol. These effects help reduce the risk of hypertension and atherosclerosis.\u003c\/p\u003e\u003cp\u003e• Anti-Allergic Effect\u003c\/p\u003e\u003cp\u003eMechanism: Quercetin inhibits the release of histamines, alleviating allergy symptoms. It helps prevent and manage conditions like allergic rhinitis, asthma, and atopic dermatitis.\u003c\/p\u003e\u003ch3\u003e(3) Benefits of Active Folate\u003c\/h3\u003e\u003cp\u003e• \u003cb\u003ePrevention of Neural Tube Defects\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eActive folate plays a crucial role during early pregnancy, particularly in weeks 3 to 4, when the fetal brain and spinal cord are forming. A lack of folate during this critical period can lead to congenital abnormalities such as neural tube defects (NTDs). Unlike regular folate, active folate can be immediately utilized by the body without requiring conversion, making it more effective in supporting the health of both the mother and fetus.\u003c\/p\u003e\u003cp\u003eResearch indicates that sufficient intake of active folate prior to pregnancy can reduce the risk of NTDs by more than 50%.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: Folic acid for the prevention of neural tube defects. American Academy of Pediatrics. Committee on Genetics. Pediatrics. 1999 Aug;104(2 Pt 1):325-7. doi: 10.1542\/peds.104.2.325. PMID: 10429019.a\u003c\/p\u003e\u003cp\u003e• \u003cb\u003eCardiovascular Health\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eActive folate contributes to lowering blood homocysteine levels, which is crucial for cardiovascular health. Elevated homocysteine concentrations can damage arteries and lead to blood clots, significantly increasing the risk of cardiovascular diseases. Active folate aids in the methylation of homocysteine, converting it into methionine, which also supports red blood cell production and overall vascular health.\u003c\/p\u003e\u003cp class=\"reference\"\u003eReference: 바이오타임즈, 혈관 질환을 유발하는 호모시스테인, 엽산과 비타민B12 함께 섭취하면 도움 https:\/\/www.biotimes.co.kr\/news\/articleView.html?idxno=11311\u003c\/p\u003e\u003cp\u003e• \u003cb\u003eMental Health and Mood Support\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eFolate is essential for the synthesis of neurotransmitters, particularly in regulating serotonin, known as the \"happiness hormone,\" and dopamine, a key component of the brain's reward system. By supporting the production and balance of these neurotransmitters, folate can help alleviate depression and anxiety.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-3')\"\u003e Why ROKIT WOMENPLUS Stands Out \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-3\" class=\"accordion-content\"\u003e\u003cp\u003eROKIT WOMENPLUS combines three key ingredients, creating synergistic effects that enhance their individual benefits.\u003c\/p\u003e\u003cp\u003e• Synergy in Antioxidant and Anti-Inflammatory Action\u003c\/p\u003e\u003cp\u003eTrans-Resveratrol and Quercetin both possess antioxidant and anti-inflammatory properties. Together, they effectively eliminate reactive oxygen species (ROS) and suppress inflammatory pathways (e.g., NF-κB), preventing cellular aging and neurodegeneration.\u003c\/p\u003e\u003cp\u003e• Enhanced Brain Health\u003c\/p\u003e\u003cp\u003eBoth Trans-Resveratrol and Quercetin improve neuroprotection, promoting in memory and learning capacity enhancement.\u003c\/p\u003e\u003cp\u003e• Improved Cardiovascular Health\u003c\/p\u003e\u003cp\u003eFolate reduces homocysteine levels, promoting cardiovascular health. When combined with the antioxidant effects of Trans-Resveratrol and Quercetin, it provides a powerful synergy for preventing cardiovascular diseases.\u003c\/p\u003e\u003cp\u003eWhy Choose ROKIT America’s WOMENPLUS?\u003c\/p\u003e\u003ch3\u003e1. High-Quality Ingredients with Optimal Ratios\u003c\/h3\u003e\u003cp\u003eWOMENPLUS is formulated with Trans-Resveratrol, Quercetin Dihydrate, Active Folate, and other nutrients tailored to women’s health, ensuring the optimal balance for maximizing individual benefits and synergistic effects.\u003c\/p\u003e\u003ch3\u003e2. Enhanced Absorption and Bioavailability\u003c\/h3\u003e\u003cp\u003eThe product uses advanced ingredients with improved absorption, ensuring effective action within the body.\u003c\/p\u003e\u003ch3\u003e3. Safety and Research-Based Manufacturing\u003c\/h3\u003e\u003cp\u003eCrafted with carefully verified ingredients, WOMENPLUS undergoes meticulous quality control at every stage of production. It is manufactured in NSF GMP-certified facilities in the United States, ensuring dependable and consistent quality.\u003c\/p\u003e\u003ch3\u003e4. A Formula Designed for Women’s Health\u003c\/h3\u003e\u003cp\u003eWOMENPLUS addresses key health concerns for women, such as stress relief, memory enhancement, and homocysteine level reduction, providing comprehensive support for overall well-being.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-2\" class=\"tabcontent-cus\"\u003e\u003c\/div\u003e\u003cdiv id=\"tab-3\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eDaily Intake\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e2 capsules : Folate (400 mcg), Trans-Resveratrol (350 mg), and Quercetin (80 mg).\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003eMethyltetrahydrofolate Glucosamine, Trans-Resveratrol, Quercetin, and Rice Bran Extract.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eSuggested Use\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eTake 2 capsules daily after meals, or as directed by your physician.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eRecommended Age\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eAges 34 to 60+.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"supplement_fact_pannel\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/WOMEN_PLUS.png?v=1723192062\" alt=\"영양 성분표\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-4\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003ca href=\"https:\/\/unipass.customs.go.kr\/csp\/persIndex.do\" class=\"custom-button\" target=\"_blank\" 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AMERICA","offers":[{"title":"Single","offer_id":40057249792073,"sku":"RA-FG-WM1","price":34.35,"currency_code":"USD","in_stock":true},{"title":"3-Month Supply","offer_id":55426933391433,"sku":"RA-FG-WM2","price":103.04,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/womenplus_1000.png?v=1782721856"},{"product_id":"스퍼미딘-60캡슐","title":"\u003ctc\u003eNMN Pterostillbene 60 Capsules\u003c\/tc\u003e","description":"\u003ctc\u003e\u003cdiv id=\"tab-1\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"plus-tab-customizing\"\u003e\u003cdiv class=\"plus-tab-customizing-title\"\u003e\u003ch3\u003eWhat is the NMN Pterostilbene?\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-container\"\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-1')\"\u003e What Makes ROKIT NMN Special \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-1\" class=\"accordion-content\"\u003e\u003cp\u003eNMN (Nicotinamide Mononucleotide) is a precursor to NAD+, a vital coenzyme found in all cells of the body. NAD+ plays an essential role in various biological processes, including energy metabolism, DNA repair, and the regulation of cellular aging.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/1._NAD.gif?v=1732689254\" alt=\"NMN 이미지\" class=\"responsive-image\" \u003e\u003cp\u003eNAD+ levels naturally decline with age, but this can be supplemented through NMN intake. Since NAD+ itself cannot be absorbed directly into the body, consuming NMN, which converts to NAD+ within the body, is the most effective method. Harvard University’s pioneering aging researcher, David A. Sinclair, highlighted NMN supplementation as a key to managing aging in his book Lifespan: Why We Age – and Why We Don’t Have To bringing global attention to its potential benefits.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/2._NMN.jpg?v=1732689555\" alt=\"NMN 분자구조\" class=\"responsive-image\" \u003e\u003cp\u003eROKIT America, in collaboration with ROKIT Healthcare, is spearheading the global anti-aging market by utilizing rigorously verified \"ROKIT NMN\" ingredients. The exceptional qualities of ROKIT NMN products are as follows:\u003c\/p\u003e\u003ch3\u003eScience-Based Research:\u003c\/h3\u003e\u003cp\u003eROKIT America develops its products based on the safety testing results of ROKIT NMN conducted jointly with ROKIT Healthcare. To validate the safety of NMN, it is essential to confirm the absence of toxicity in the raw materials through comprehensive toxicity testing. This is a critical factor in building trust in the product. ROKIT Healthcare has conducted the following tests to demonstrate the safety of ROKIT NMN:\u003c\/p\u003e\u003cdiv class=\"button-container\"\u003e\u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/rokit_nmn_toxicity_test_safety_experiment_1\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Single-Dose Toxicity Test Results\u003c\/a\u003e \u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/%EB%A1%9C%ED%82%B7%EC%95%84%EB%A9%94%EB%A6%AC%EC%B9%B4-%EC%97%B0%EA%B5%AC%EC%9E%90%EB%A3%8C-nmn-%EB%8F%85%EC%84%B1%EC%8B%9C%ED%97%98-%EC%95%88%EC%A0%84%EC%84%B1-%ED%8F%89%EA%B0%80-%EB%B0%98%EB%B3%B5%ED%88%AC%EC%97%AC\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Repeated-Dose Toxicity Test Results\u003c\/a\u003e \u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/%EB%A1%9C%ED%82%B7%EC%95%84%EB%A9%94%EB%A6%AC%EC%B9%B4-%EC%97%B0%EA%B5%AC%EC%9E%90%EB%A3%8C-nmn%EC%9D%98-%EC%9C%A0%EC%A0%84-%EB%8F%85%EC%84%B1%EC%8B%9C%ED%97%98-%EB%B3%B5%EA%B7%80%EB%8F%8C%EC%97%B0%EB%B3%80%EC%9D%B4-%ED%8F%89%EA%B0%80\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Reproductive and Developmental Toxicity Test Results\u003c\/a\u003e\u003c\/div\u003e\u003ch3\u003eHigh Purity and Superior Absorption:\u003c\/h3\u003e\u003cp\u003eROKIT America’s NMN products are manufactured with 99.9% purity, ensuring exceptional absorption within the body. The product is formulated with precise amounts of high-quality raw materials to maximize its effectiveness at the cellular level.\u003c\/p\u003e\u003ch3\u003eSafety and Verified Quality:\u003c\/h3\u003e\u003cp\u003eEach ROKIT NMN product undergoes stringent quality control measures and is manufactured in compliance with international standards. This ensures the delivery of safe and reliable products that users can trust.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-2')\"\u003e What is Pterostilbene? \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-2\" class=\"accordion-content\"\u003e\u003cp\u003ePterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural polyphenol compound primarily found in blueberries. Known for its higher bioavailability compared to other stilbene compounds, pterostilbene can significantly enhance the absorption efficiency of NMN. Studies have shown that pterostilbene’s bioavailability is approximately 80%, compared to only 20% for resveratrol, while offering many of the same beneficial biological regulatory effects as resveratrol.\u003c\/p\u003e\u003ch3\u003eKey Benefits and Functions of Pterostilbene:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Powerful Antioxidant Activity: Pterostilbene effectively eliminates reactive oxygen species (ROS) and reduces oxidative stress (OS), playing a crucial role in antioxidant defense. Its antioxidant properties are linked to benefits such as anti-cancer effects, neurological disease management, anti-inflammatory effects, vascular health improvement, and diabetes alleviation.\u003cbr\u003e• AMPK Activation: Pterostilbene activates AMPK, improving insulin resistance and promoting autophagy in the body. Enhanced autophagy activates SIRT2 proteins, which are essential for cell survival, DNA repair, antioxidant activity, and metabolic regulation.\u003cbr\u003e• Inflammation Mitigation in Osteoarthritis: Studies have shown that administering pterostilbene to mice with osteoarthritis reduced inflammatory mediators like COX-2, iNOS, and PGE2 induced by IL-1β. Additionally, mitochondrial and intracellular ROS production was significantly suppressed. Since COX-2 and PGE2 are key mediators of inflammation-induced osteoarthritis pain, these findings suggest that pterostilbene can effectively reduce low-level inflammation in cartilage cells.\u003c\/p\u003e\u003cp class=\"reference\"\u003eXue EX, Lin JP, Zhang Y, Sheng SR, Liu HX, Zhou YL, Xu H. Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Oncotarget. 2017 Jun 27;8(26):41988-42000. doi: 10.18632\/oncotarget.16716. PMID: 28410217; PMCID: PMC5522043.\u003c\/p\u003e\u003ch3\u003eNeuroprotective Effects:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Effective Blood-Brain Barrier Penetration: Pterostilbene effectively crosses the blood-brain barrier, helping to prevent neurodegenerative diseases. \u003cbr\u003e• Reduction of Oxidative Stress and Inflammation in Neural Tissue: It reduces oxidative stress and inflammation in neural tissue, enhancing cognitive function and memory. Studies have demonstrated that aged mice supplemented with pterostilbene showed improvements across various indicators, including cognitive abilities, behavior, memory tests, and mitochondrial function, which is the primary energy source for cells.\u003cbr\u003e• Enhancement of Learning and Memory Proteins: Pterostilbene supplementation increased the expression of PSD-95, a protein involved in learning and memory formation. This suggests its potential to alleviate functional impairments associated with Alzheimer’s disease.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/nmn_9bbe08e2-2c1b-4329-a239-0cd576a757ee.png?v=1732693258\" alt=\"NMN 이미지\" class=\"responsive-image\" \u003e\u003cp\u003e▲ Behavioral Assessment of Pterostilbene's Effects on Cognitive Function.\u003c\/p\u003e\u003cp\u003eIn (A), there was no difference between the two groups before treatment (p = 0.619), but after pterostilbene administration, the pterostilbene-treated group showed better performance compared to the control group (p = 0.013). In (B), the pterostilbene-treated group demonstrated a superior ability to distinguish objects compared to the control group (p = 0.003). In both (C) and (D), the pterostilbene-treated group outperformed the control group, successfully distinguishing between the two objects at both 1-hour and 24-hour intervals (p \u0026lt; 0.001 and p = 0.002, respectively).\u003c\/p\u003e\u003cp class=\"reference\"\u003eLa Spina M, Sansevero G, Biasutto L, Zoratti M, Peruzzo R, Berardi N, Sale A, Azzolini M. Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Cell Physiol Biochem. 2019;52(2):232-239. doi: 10.33594\/000000017. Epub 2019 Feb 28. PMID: 30816671.\u003c\/p\u003e\u003ch3\u003eCardiovascular Health:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Helps lower LDL cholesterol and triglyceride levels while increasing HDL cholesterol. \u003cbr\u003e• Prevents lipid oxidation, reducing the risk of atherosclerosis and cardiovascular diseases.\u003c\/p\u003e\u003ch3\u003eMetabolic Health and Diabetes Management:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Improves insulin sensitivity and regulates blood sugar levels. \u003cbr\u003e• Enhances lipid metabolism, supporting weight management.\u003c\/p\u003e\u003ch3\u003eAnticancer Potential:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Induces apoptosis (programmed cell death) in cancer cells and inhibits their proliferation. \u003cbr\u003e• Demonstrates efficacy against various cancer cell lines, including breast, colon, and lung cancers.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-3')\"\u003e THE BENEFIT OF NMN PTEROSTILBENE \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-3\" class=\"accordion-content\"\u003e\u003ch3\u003eSynergy Between NMN and Stilbene Compounds: Cellular Protection and Anti-Aging Effects\u003c\/h3\u003e\u003cp\u003eResearch indicates that combining NAD+ boosters like NMN with stilbene compounds amplifies their antioxidant and anti-aging effects.\u003c\/p\u003e\u003cp class=\"bullet\"\u003eCo-administration of NMN and Resveratrol: This combination resulted in higher NAD+ levels in the heart and skeletal muscles compared to NMN alone.\u003cbr\u003e• Co-administration of NMN and Ginsenosides: This pairing maximized NAD+ levels in brain, heart, kidney, and lung tissues, significantly surpassing the effects of NMN alone. \u003cbr\u003e• Co-administration of NR and Pterostilbene: In patients with acute kidney injury, this combination increased NAD+ levels by 40% and 90% after two doses, with consistent improvements observed throughout an 8-week trial period.\u003c\/p\u003e\u003cp\u003eThus, the combination of NMN with stilbene compounds represents an optimal approach for maximizing NAD+ levels and supporting longevity.\u003c\/p\u003e\u003cp class=\"reference\"\u003eSharma A, Chabloz S, Lapides RA, Roider E, Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023 Jan 14;15(2):445. DOI: 10.3390\/nu15020445. PMID: 36678315; PMCID: PMC9861325.\u003c\/p\u003e\u003ch3\u003eSynergy Between NMN and Pterostilbene: Cellular Protection and Anti-Aging Effects\u003c\/h3\u003e\u003cp\u003eThe synergy observed when NMN and Pterostilbene are taken together stems from their complementary mechanisms of cellular protection.\u003c\/p\u003e\u003cp class=\"bullet\"\u003e• Increased Cellular Energy Through NAD+ Supplementation: NMN boosts NAD+ levels, enhancing cellular energy, aiding cell regeneration, and promoting lifespan extension.\u003cbr\u003e• Antioxidant and Anti-inflammatory Effects: Pterostilbene reduces oxidative stress and suppresses inflammatory responses, preventing cellular damage and maintaining a healthy cellular environment.\u003c\/p\u003e\u003cp\u003eWhen combined, these mechanisms reinforce cellular resilience, protect against oxidative and inflammatory damage, and ensure sufficient cellular energy. This synergy results in enhanced fatigue recovery, chronic disease prevention, and amplified anti-aging effects.\u003c\/p\u003e\u003ch3\u003eStilbene Compounds: Pterostilbene vs. Resveratrol\u003c\/h3\u003e\u003cp\u003eWhen NMN is paired with Pterostilbene, the combined effects include NAD+ elevation for energy production and Pterostilbene's antioxidant properties, offering multifaceted cellular protection. This is because NMN converts into NAD+ within cells, serving as fuel for the longevity gene Sirtuin, while Pterostilbene acts as a Sirtuin activator. Research highlights that compared to Resveratrol, Pterostilbene is a safer and longer-lasting compound for delaying aging through sustained NAD+ presence in the body. Additionally: Conversion of Resveratrol to Pterostilbene: Resveratrol undergoes O-Methyltransferase action, replacing two hydroxyl hydrogen atoms with methyl groups to form Pterostilbene. Enhanced Retention and Absorption: Pterostilbene, being lipophilic, delays the excretion of NMN, allowing it to remain in the body longer. Furthermore, while Resveratrol has low oral bioavailability, Pterostilbene is absorbed over four times more efficiently. In conclusion, the combination of NMN and Pterostilbene not only boosts NAD+ levels but also amplifies the individual benefits of both compounds, making it the \"optimal anti-aging formula.\"\u003c\/p\u003e\u003cdiv class=\"image-row-1\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/e1de51b6590ceadab74cc5b197c3d6bb.png?v=1732757010\" alt=\"NMN 연구보고서 2\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-2\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003cimg src=\"https:\/\/store.img11.co.kr\/68904879\/bb9cec8b-2c7a-4b4a-9e17-17d585132392_1731543306010.png\" alt=\"제품 이미지 1\" \u003e \u003cimg src=\"https:\/\/store.img11.co.kr\/68904879\/5fc448ae-feb7-4362-96b3-9d6b9e5c224c_1731483835901.png\" alt=\"제품 이미지 2\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-3\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eDaily Intake\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e2 capsules : NMN(250mg) + Pterostilbene(250mg)\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003eNicotinamide Mononucleotide (NMN), Pterostilbene, Rice Bran Extract, and Vegetable Capsule.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eSuggested Use\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eTake 1 capsule daily before breakfast, or as directed by your physician.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eRecommended Age\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eAges 34 to 60+.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv 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번째 아코디언 열기\n              document.addEventListener(\"DOMContentLoaded\", function () {\n              const accordionContents = document.querySelectorAll(\".accordion-content\");\n              const toggleIcons = document.querySelectorAll(\".toggle-icon\");\n              accordionContents.forEach((content, index) =\u003e {\n              content.classList.add(\"open\");\n              content.style.maxHeight = content.scrollHeight + \"px\";\n              if (toggleIcons[index]) {\n              toggleIcons[index].classList.add(\"rotate\");\n              }\n              });\n              });\n            \u003c\/script\u003e \u003c\/tc\u003e","brand":"ROKIT AMERICA","offers":[{"title":"Single","offer_id":55773453975625,"sku":"RA-FG-SPM1","price":42.24,"currency_code":"USD","in_stock":true},{"title":"3-Month Supply(29%OFF)","offer_id":55773454008393,"sku":"RA-FG-SPM2","price":119.69,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/spermidine_1000.png?v=1782786783"},{"product_id":"fisetin-stick-powder","title":"\u003ctc\u003eNMN Pterostillbene 60 Capsules\u003c\/tc\u003e","description":"\u003ctc\u003e\u003cdiv id=\"tab-1\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"plus-tab-customizing\"\u003e\u003cdiv class=\"plus-tab-customizing-title\"\u003e\u003ch3\u003eWhat is the NMN Pterostilbene?\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-container\"\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-1')\"\u003e What Makes ROKIT NMN Special \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-1\" class=\"accordion-content\"\u003e\u003cp\u003eNMN (Nicotinamide Mononucleotide) is a precursor to NAD+, a vital coenzyme found in all cells of the body. NAD+ plays an essential role in various biological processes, including energy metabolism, DNA repair, and the regulation of cellular aging.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/1._NAD.gif?v=1732689254\" alt=\"NMN 이미지\" class=\"responsive-image\" \u003e\u003cp\u003eNAD+ levels naturally decline with age, but this can be supplemented through NMN intake. Since NAD+ itself cannot be absorbed directly into the body, consuming NMN, which converts to NAD+ within the body, is the most effective method. Harvard University’s pioneering aging researcher, David A. Sinclair, highlighted NMN supplementation as a key to managing aging in his book Lifespan: Why We Age – and Why We Don’t Have To bringing global attention to its potential benefits.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/2._NMN.jpg?v=1732689555\" alt=\"NMN 분자구조\" class=\"responsive-image\" \u003e\u003cp\u003eROKIT America, in collaboration with ROKIT Healthcare, is spearheading the global anti-aging market by utilizing rigorously verified \"ROKIT NMN\" ingredients. The exceptional qualities of ROKIT NMN products are as follows:\u003c\/p\u003e\u003ch3\u003eScience-Based Research:\u003c\/h3\u003e\u003cp\u003eROKIT America develops its products based on the safety testing results of ROKIT NMN conducted jointly with ROKIT Healthcare. To validate the safety of NMN, it is essential to confirm the absence of toxicity in the raw materials through comprehensive toxicity testing. This is a critical factor in building trust in the product. ROKIT Healthcare has conducted the following tests to demonstrate the safety of ROKIT NMN:\u003c\/p\u003e\u003cdiv class=\"button-container\"\u003e\u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/rokit_nmn_toxicity_test_safety_experiment_1\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Single-Dose Toxicity Test Results\u003c\/a\u003e \u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/%EB%A1%9C%ED%82%B7%EC%95%84%EB%A9%94%EB%A6%AC%EC%B9%B4-%EC%97%B0%EA%B5%AC%EC%9E%90%EB%A3%8C-nmn-%EB%8F%85%EC%84%B1%EC%8B%9C%ED%97%98-%EC%95%88%EC%A0%84%EC%84%B1-%ED%8F%89%EA%B0%80-%EB%B0%98%EB%B3%B5%ED%88%AC%EC%97%AC\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Repeated-Dose Toxicity Test Results\u003c\/a\u003e \u003ca href=\"https:\/\/rokitamerica.com\/blogs\/blog\/%EB%A1%9C%ED%82%B7%EC%95%84%EB%A9%94%EB%A6%AC%EC%B9%B4-%EC%97%B0%EA%B5%AC%EC%9E%90%EB%A3%8C-nmn%EC%9D%98-%EC%9C%A0%EC%A0%84-%EB%8F%85%EC%84%B1%EC%8B%9C%ED%97%98-%EB%B3%B5%EA%B7%80%EB%8F%8C%EC%97%B0%EB%B3%80%EC%9D%B4-%ED%8F%89%EA%B0%80\" target=\"_blank\" class=\"custom-button\" rel=\"noopener\"\u003eROKIT NMN Reproductive and Developmental Toxicity Test Results\u003c\/a\u003e\u003c\/div\u003e\u003ch3\u003eHigh Purity and Superior Absorption:\u003c\/h3\u003e\u003cp\u003eROKIT America’s NMN products are manufactured with 99.9% purity, ensuring exceptional absorption within the body. The product is formulated with precise amounts of high-quality raw materials to maximize its effectiveness at the cellular level.\u003c\/p\u003e\u003ch3\u003eSafety and Verified Quality:\u003c\/h3\u003e\u003cp\u003eEach ROKIT NMN product undergoes stringent quality control measures and is manufactured in compliance with international standards. This ensures the delivery of safe and reliable products that users can trust.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-2')\"\u003e What is Pterostilbene? \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-2\" class=\"accordion-content\"\u003e\u003cp\u003ePterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural polyphenol compound primarily found in blueberries. Known for its higher bioavailability compared to other stilbene compounds, pterostilbene can significantly enhance the absorption efficiency of NMN. Studies have shown that pterostilbene’s bioavailability is approximately 80%, compared to only 20% for resveratrol, while offering many of the same beneficial biological regulatory effects as resveratrol.\u003c\/p\u003e\u003ch3\u003eKey Benefits and Functions of Pterostilbene:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Powerful Antioxidant Activity: Pterostilbene effectively eliminates reactive oxygen species (ROS) and reduces oxidative stress (OS), playing a crucial role in antioxidant defense. Its antioxidant properties are linked to benefits such as anti-cancer effects, neurological disease management, anti-inflammatory effects, vascular health improvement, and diabetes alleviation.\u003cbr\u003e• AMPK Activation: Pterostilbene activates AMPK, improving insulin resistance and promoting autophagy in the body. Enhanced autophagy activates SIRT2 proteins, which are essential for cell survival, DNA repair, antioxidant activity, and metabolic regulation.\u003cbr\u003e• Inflammation Mitigation in Osteoarthritis: Studies have shown that administering pterostilbene to mice with osteoarthritis reduced inflammatory mediators like COX-2, iNOS, and PGE2 induced by IL-1β. Additionally, mitochondrial and intracellular ROS production was significantly suppressed. Since COX-2 and PGE2 are key mediators of inflammation-induced osteoarthritis pain, these findings suggest that pterostilbene can effectively reduce low-level inflammation in cartilage cells.\u003c\/p\u003e\u003cp class=\"reference\"\u003eXue EX, Lin JP, Zhang Y, Sheng SR, Liu HX, Zhou YL, Xu H. Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Oncotarget. 2017 Jun 27;8(26):41988-42000. doi: 10.18632\/oncotarget.16716. PMID: 28410217; PMCID: PMC5522043.\u003c\/p\u003e\u003ch3\u003eNeuroprotective Effects:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Effective Blood-Brain Barrier Penetration: Pterostilbene effectively crosses the blood-brain barrier, helping to prevent neurodegenerative diseases. \u003cbr\u003e• Reduction of Oxidative Stress and Inflammation in Neural Tissue: It reduces oxidative stress and inflammation in neural tissue, enhancing cognitive function and memory. Studies have demonstrated that aged mice supplemented with pterostilbene showed improvements across various indicators, including cognitive abilities, behavior, memory tests, and mitochondrial function, which is the primary energy source for cells.\u003cbr\u003e• Enhancement of Learning and Memory Proteins: Pterostilbene supplementation increased the expression of PSD-95, a protein involved in learning and memory formation. This suggests its potential to alleviate functional impairments associated with Alzheimer’s disease.\u003c\/p\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/nmn_9bbe08e2-2c1b-4329-a239-0cd576a757ee.png?v=1732693258\" alt=\"NMN 이미지\" class=\"responsive-image\" \u003e\u003cp\u003e▲ Behavioral Assessment of Pterostilbene's Effects on Cognitive Function.\u003c\/p\u003e\u003cp\u003eIn (A), there was no difference between the two groups before treatment (p = 0.619), but after pterostilbene administration, the pterostilbene-treated group showed better performance compared to the control group (p = 0.013). In (B), the pterostilbene-treated group demonstrated a superior ability to distinguish objects compared to the control group (p = 0.003). In both (C) and (D), the pterostilbene-treated group outperformed the control group, successfully distinguishing between the two objects at both 1-hour and 24-hour intervals (p \u0026lt; 0.001 and p = 0.002, respectively).\u003c\/p\u003e\u003cp class=\"reference\"\u003eLa Spina M, Sansevero G, Biasutto L, Zoratti M, Peruzzo R, Berardi N, Sale A, Azzolini M. Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Cell Physiol Biochem. 2019;52(2):232-239. doi: 10.33594\/000000017. Epub 2019 Feb 28. PMID: 30816671.\u003c\/p\u003e\u003ch3\u003eCardiovascular Health:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Helps lower LDL cholesterol and triglyceride levels while increasing HDL cholesterol. \u003cbr\u003e• Prevents lipid oxidation, reducing the risk of atherosclerosis and cardiovascular diseases.\u003c\/p\u003e\u003ch3\u003eMetabolic Health and Diabetes Management:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Improves insulin sensitivity and regulates blood sugar levels. \u003cbr\u003e• Enhances lipid metabolism, supporting weight management.\u003c\/p\u003e\u003ch3\u003eAnticancer Potential:\u003c\/h3\u003e\u003cp class=\"bullet\"\u003e• Induces apoptosis (programmed cell death) in cancer cells and inhibits their proliferation. \u003cbr\u003e• Demonstrates efficacy against various cancer cell lines, including breast, colon, and lung cancers.\u003c\/p\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv class=\"accordion-item\"\u003e\u003cbutton class=\"accordion-button\" onclick=\"toggleAccordion(event, 'content-3')\"\u003e THE BENEFIT OF NMN PTEROSTILBENE \u003cspan class=\"toggle-icon\"\u003e+\u003c\/span\u003e \u003c\/button\u003e\u003cdiv id=\"content-3\" class=\"accordion-content\"\u003e\u003ch3\u003eSynergy Between NMN and Stilbene Compounds: Cellular Protection and Anti-Aging Effects\u003c\/h3\u003e\u003cp\u003eResearch indicates that combining NAD+ boosters like NMN with stilbene compounds amplifies their antioxidant and anti-aging effects.\u003c\/p\u003e\u003cp class=\"bullet\"\u003eCo-administration of NMN and Resveratrol: This combination resulted in higher NAD+ levels in the heart and skeletal muscles compared to NMN alone.\u003cbr\u003e• Co-administration of NMN and Ginsenosides: This pairing maximized NAD+ levels in brain, heart, kidney, and lung tissues, significantly surpassing the effects of NMN alone. \u003cbr\u003e• Co-administration of NR and Pterostilbene: In patients with acute kidney injury, this combination increased NAD+ levels by 40% and 90% after two doses, with consistent improvements observed throughout an 8-week trial period.\u003c\/p\u003e\u003cp\u003eThus, the combination of NMN with stilbene compounds represents an optimal approach for maximizing NAD+ levels and supporting longevity.\u003c\/p\u003e\u003cp class=\"reference\"\u003eSharma A, Chabloz S, Lapides RA, Roider E, Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023 Jan 14;15(2):445. DOI: 10.3390\/nu15020445. PMID: 36678315; PMCID: PMC9861325.\u003c\/p\u003e\u003ch3\u003eSynergy Between NMN and Pterostilbene: Cellular Protection and Anti-Aging Effects\u003c\/h3\u003e\u003cp\u003eThe synergy observed when NMN and Pterostilbene are taken together stems from their complementary mechanisms of cellular protection.\u003c\/p\u003e\u003cp class=\"bullet\"\u003e• Increased Cellular Energy Through NAD+ Supplementation: NMN boosts NAD+ levels, enhancing cellular energy, aiding cell regeneration, and promoting lifespan extension.\u003cbr\u003e• Antioxidant and Anti-inflammatory Effects: Pterostilbene reduces oxidative stress and suppresses inflammatory responses, preventing cellular damage and maintaining a healthy cellular environment.\u003c\/p\u003e\u003cp\u003eWhen combined, these mechanisms reinforce cellular resilience, protect against oxidative and inflammatory damage, and ensure sufficient cellular energy. This synergy results in enhanced fatigue recovery, chronic disease prevention, and amplified anti-aging effects.\u003c\/p\u003e\u003ch3\u003eStilbene Compounds: Pterostilbene vs. Resveratrol\u003c\/h3\u003e\u003cp\u003eWhen NMN is paired with Pterostilbene, the combined effects include NAD+ elevation for energy production and Pterostilbene's antioxidant properties, offering multifaceted cellular protection. This is because NMN converts into NAD+ within cells, serving as fuel for the longevity gene Sirtuin, while Pterostilbene acts as a Sirtuin activator. Research highlights that compared to Resveratrol, Pterostilbene is a safer and longer-lasting compound for delaying aging through sustained NAD+ presence in the body. Additionally: Conversion of Resveratrol to Pterostilbene: Resveratrol undergoes O-Methyltransferase action, replacing two hydroxyl hydrogen atoms with methyl groups to form Pterostilbene. Enhanced Retention and Absorption: Pterostilbene, being lipophilic, delays the excretion of NMN, allowing it to remain in the body longer. Furthermore, while Resveratrol has low oral bioavailability, Pterostilbene is absorbed over four times more efficiently. In conclusion, the combination of NMN and Pterostilbene not only boosts NAD+ levels but also amplifies the individual benefits of both compounds, making it the \"optimal anti-aging formula.\"\u003c\/p\u003e\u003cdiv class=\"image-row-1\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0554\/8094\/2665\/files\/e1de51b6590ceadab74cc5b197c3d6bb.png?v=1732757010\" alt=\"NMN 연구보고서 2\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-2\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"image-container\"\u003e\u003cimg src=\"https:\/\/store.img11.co.kr\/68904879\/bb9cec8b-2c7a-4b4a-9e17-17d585132392_1731543306010.png\" alt=\"제품 이미지 1\" \u003e \u003cimg src=\"https:\/\/store.img11.co.kr\/68904879\/5fc448ae-feb7-4362-96b3-9d6b9e5c224c_1731483835901.png\" alt=\"제품 이미지 2\" \u003e\u003c\/div\u003e\u003c\/div\u003e\u003cdiv id=\"tab-3\" class=\"tabcontent-cus\"\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eDaily Intake\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e2 capsules : NMN(250mg) + Pterostilbene(250mg)\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003eNicotinamide Mononucleotide (NMN), Pterostilbene, Rice Bran Extract, and Vegetable Capsule.\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eSuggested Use\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eTake 1 capsule daily before breakfast, or as directed by your physician.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv class=\"pdp_des\"\u003e\u003cdiv class=\"tit\"\u003e\u003cspan\u003eRecommended Age\u003c\/span\u003e\u003c\/div\u003e\u003cp class=\"con\"\u003e\u003cspan\u003eAges 34 to 60+.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cdiv 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