Does NutraJIT® technology help with the absorption of NMN?

NutraJIT® Technology Will it help with the absorption of NMN ?

NMN is When it stays in the intestines and is released for a long time, its absorption rate in the body increases.

However, there is a barrier that orally taken NMN capsules must pass through to reach the small intestine.

as soon as It's above .

• The stomach cannot absorb NMN .

Above is It emits acid with a pH of 1. pH is an indicator of the acidity of a solution, which is the hydrogen ion index of an aqueous solution made with water as a solvent . It is neutral. Based on pH 7 , a value lower than that means acidity , and a value higher than that means alkaline . Then How acidic is pH 1 ?

pH = - log[H+]

pH can be calculated by taking the negative logarithm of the concentration of hydrogen ions.

Let me explain it simply . Vinegar pH is 3~4 is better than this It is 10 to 100 times stronger , and since the pH of hydrochloric acid is 1 , gastric acid has the same value as hydrochloric acid . This is because the concentration of hydrogen ions is higher than the neutral value of pH 7. It is a million times higher. It is not harmful to the human body because the concentration of gastric acid in the stomach is low .

When the capsules remain in the lowered acidity of the stomach, they quickly dissolve , even before reaching the small intestine .

• The small intestine is the digestive organ that can absorb NMN .

The digestive system that can fully accept NMN is It's a ' small intestine ' . This means that the small intestine is This is because it has the most NMN transport protein, Scl12A8 .

In vivo Scl12A8 Let me briefly introduce a paper on how well NMN is transported . The control group 'Lentivirus carrying fLuc shRNA ' and When 'lentivirus carrying Slc12a8 shRNA ' was orally administered to each mouse ,

The concentration of Slc12a8 protein is < Compared to control mice > < Slc12a8 shRNA carrying lentivirus In the administered ( Slc12a8-KD ) mice > there was a 60% decrease in the factory and a 50% decrease in the ileum . Below In Figure a, you can see that the red box area is clearly softened , which means In the small intestine of Slc12a8-KD mice This means that the amount of Slc12a8 protein is reduced . A low concentration of Slc12a8 protein means that “ In the small intestine Slc12a8 This can be interpreted as “protein is used to transport NMN to various parts of the body, so the amount remaining after use is small . ”

Next weight To a 500g rat In control rats, when NMN was administered orally, Plasma within 5 minutes The concentration of NMN increased You can check it with the blue box in Figure b . When NMN is continuously administered , the amount administered is The increase in NMN concentration is This means that NMN is not converted to NAD+ and remains in the NMN form .

In contrast, in Slc12a8-KD mice, plasma The concentration of NMN did not increase As can be seen in the green box in Figure b , even though NMN was continuously administered , the amount administered was That is, the NMN concentration did not increase. This means that instead of staying in the NMN form, it is broken down into the NAD+ form that our bodies need .

Not increased Looking at the orange box in Figure c , in contrast to the green box in Figure b , we can see that the NAD+ concentration in Slc12a8-KD mice is clearly increased . The concentration of plasma NAD+ tends to be higher in Slc12a8-KD mice , which is Slc12a8-KD mice showed NMN This is because the level of breakdown into NAD+ is high .

These results suggest that small intestinal Slc12a8 is important for transporting NMN from the intestine to the circulation, thereby influencing systemic NMN supply in vivo.

• Rocket America is The capsule that has passed through the ' above ' is completely Move to ' Corporal ' .

Rocket America thought .

' Is there no way to get the NMN that passes through the stomach all the way to the small intestine?'

Let's assume that the capsule, which has not dissolved in the stomach acid, reaches the small intestine intact .

When NMN is released from the capsule that begins to dissolve upon reaching the small intestine , it can be better absorbed into cells as it remains in contact with the NMN transport protein, Scl12A8 , for a longer period of time . The water-soluble nutrients (NMN) absorbed through the capillaries are absorbed through the blood circulation and transported to the tissue cells that need them via the hepatic vein , inferior vena cava , and heart, where they greatly increase the NAD+ content .

So Rocket America I came across NutraJIT® .

NutraJIT® patented technology forms a gel barrier when the capsule reaches the stomach, protecting the active ingredients from the stomach's acidity . The NMN component reaches the small intestine safely and is stored within the small intestine. It is absorbed more slowly as the pH increases .

Rocket America's NMN Long-Lasting is Combined with NutraJIT® technology Protects NMN from stomach acid and intestinal NMN absorption rate compared to other companies 7 times has been raised . The table below shows the rocket's Check out how long NMN takes to absorb !

For those who want to absorb everything without missing any effects , NMN Long-Lasting I highly recommend it .

* At Aventus According to , NutraJIT® food From protein It was created and 100% Natural It is a natural ingredient and does not contain any allergens.

[ Reference material ]

[1] Slc12a8 is a nicotinamide mononucleotide transporter: `Alessia Grozio,1 Kathryn F. Mills,1 Jun Yoshino,2 Santina Bruzzone,3 Giovanna Sociali,3 Kyohei Tokizane,1 Hanyue Cecilia Lei,1 Richard Cunningham,4 Yo Sasaki,5 Marie E. Migaud,4 and Shin-ichiro Imai1,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530925/

[2] PROTECT FROM GASTRIC FLUIDS CONTROL THE RELEASE OF YOUR PRODUCTSSHIELD FROM ACTIVE INGREDIENTS SIDE EFFECTS
https://aventusinnovations.com/NutraJit-technology.php

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